ABSTRACT
Objective: To determine the prognostic influence of serum inflammatory markers along with prognostic markers and their outcomes among patients with pre- and post-operative colorectal carcinoma.
Material and methods: This cross-sectional descriptive study was done at department of Surgery, surgical unit-II, Liaquat University Hospital, Hyderabad/Jamshoro, after 06 month after the approval of synopsis. All the patient of 20-60 years of age, either gender having history of bleeding per rectum or mucous discharge, tenesmus, altered bowl habits with weight loss for ≥ 1 month duration diagnosed as colorectal cancer on histopathologic report regardless of stage & grade presented at surgical unit-II, Liaquat University Hospital Hyderabad/Jamshoro were included.
Results: A total of 112 cases were studied; their mean age was 45.16+10.52 years. Males 51.8% and females were 48.2%. The majority of the cases had abdominal pain, per rectal bleeding and weight loss and 89.3% patients had anemia. Most of the cases 84.8% had tumor location in colon and 28.6% had tumor in rectum. According to the pre-operative assessment of the inflammatory prognostic marker, WBC were raised in 59.8% of the cases, CRP was raised in 87.5% of the patients, 77.7% patients had decreased serum albumin, 61.6% had raised ESR, raised ferritin level was in 65.2% of the cases and raised LDH was in 60.7%. In accordance to the post-operative assessment of the inflammatory prognostic marker, WBC were raised in 92.9% of the cases, CRP was raised in 94.6% of the patients, 82.1% patients had decreased serum albumin, 68.8% had raised ESR, raised ferritin level was in 69.6% of the cases and raised LDH was in 73.2%. Wound infection, pneumonia, sepsis and prolonged hospital stays were the commonest complications.  According to the Hospital mortality, 3.6% were died during hospital stay.
Conclusion: As per the study conclusion, there was significant prognostic influence of serum inflammatory markers. These markers also observed to be the significant predictors of adverse outcome among patient undergoing surgical treatment with colorectal carcinoma.
key words: Carcinoma, colon, rectum, biomarkers, mortality