ABSTRACT
Background: Diabetic complications, including neuropathy, nephropathy, and retinopathy, pose significant challenges to individuals living with diabetes. Understanding the underlying pathological mechanisms driving the development of these complications is crucial for the advancement of treatment and prevention strategies. This study aims to investigate the intricate pathways and mechanisms involved in the development of diabetic complications, focusing on neuropathy, nephropathy, and retinopathy, among a cohort of 90 patients.
Aim: The primary objective of this research is to unravel the intricate pathological mechanisms contributing to the onset and progression of diabetic complications, specifically neuropathy, nephropathy, and retinopathy, among a group of 90 patients. By gaining a deeper understanding of these mechanisms, we aim to identify potential targets for therapeutic intervention and improve the overall management of diabetes-related complications.
Methods: This study was conducted at the Liaquat National Hospital in Karachi over a period of one year, from January 2023 to January 2024. Ninety patients with diabetes were enrolled in the study, and a comprehensive range of clinical, biochemical, and molecular assessments were performed. Nerve conduction studies, kidney function tests, retinal examinations, and genomic analysis were carried out to investigate the pathological processes associated with neuropathy, nephropathy, and retinopathy. Data analysis was conducted using appropriate statistical methods to identify correlations and potential mechanisms.
Results: Preliminary findings reveal a complex interplay of various biochemical and molecular pathways contributing to the development of diabetic complications. Nerve conduction studies demonstrated evidence of peripheral neuropathy, while kidney function tests indicated signs of nephropathy. Retinal examinations revealed early signs of retinopathy. Genomic analysis unveiled potential genetic predispositions that may contribute to the susceptibility of diabetic complications. Further detailed analysis is ongoing, and the results will be presented in the full study.
Conclusion: This study provides essential insights into the pathological mechanisms underlying diabetic complications, specifically neuropathy, nephropathy, and retinopathy, in a cohort of 90 patients. Understanding these mechanisms is crucial for the development of targeted therapies and improved prevention strategies. The final results of this research will shed light on potential treatment options and avenues for further investigation, ultimately benefiting individuals living with diabetes and healthcare providers.
Keywords: Diabetes, Diabetic Complications, Neuropathy, Nephropathy, Retinopathy, Pathological Mechanisms, Liaquat National Hospital, Karachi, Genomic Analysis, Therapeutic Intervention, Prevention Strategies.