ABSTRACT:

Background: Vitamin D deficiency is common in patients with chronic kidney disease (CKD) and has been implicated in various adverse health outcomes. Additionally, hyperuricemia, characterized by elevated serum uric acid levels, often coexists in CKD patients, potentially exacerbating renal impairment.
Aim: This study aimed to determine the prevalence of vitamin D deficiency among CKD patients and its association with hyperuricemia, along with identifying related risk factors and clinical outcomes.
Methods: A cross-sectional analysis was conducted involving 200 patients diagnosed with CKD. Serum levels of vitamin D and uric acid were measured, alongside clinical parameters such as age, sex, body mass index (BMI), and comorbidities. Statistical analyses, including correlation and regression models, were employed to evaluate the associations between vitamin D levels, hyperuricemia, and clinical outcomes.
Results: The findings revealed that 65% of the CKD patients exhibited vitamin D deficiency. A significant association was observed between low vitamin D levels and hyperuricemia, with patients having vitamin D deficiency presenting higher uric acid levels (p < 0.05). Furthermore, risk factors including advanced age, higher BMI, and the presence of diabetes mellitus were identified as significant contributors to vitamin D deficiency and hyperuricemia in the CKD population.
Conclusion: The study concluded that vitamin D deficiency is prevalent in CKD patients and is significantly associated with hyperuricemia. These findings underscore the need for routine screening and management of vitamin D levels in CKD patients to potentially improve their clinical outcomes.
Keywords: Chronic Kidney Disease, Vitamin D Deficiency, Hyperuricemia, Risk Factors, Clinical Outcomes.